But Pfizer knew otherwise…
Our concerns
Transparency: it seems a leopard can’t change its spots
Did you get the impression that that the new generation mRNA vaccines are limited to the site of injection in the deltoid muscle and don’t get into your circulation, so are not distributed through the body?
The theory has always tended to sound neat and tidy. The lipid nanoparticle encapsulates the delicate mRNA and helps it get into the cell contents (cytosol). That’s when the magic begins, neatly summarised in the UK MHRA’s Public Assessment Report on the Pfizer/BioNTech vaccine:
“In the cytosol, the RNA is translated into the encoded viral protein. The viral spike (S) protein antigen induces an adaptive immune response through neutralising antibodies. Furthermore, as the expressed spike (S) protein is being degraded intracellularly, the resulting peptides can be presented at the cell surface, triggering a specific T cell-mediated immune response with activity against the virus and infected cells.”
– UK MHRA Public Assessment Report (updated 20 May 2021)
There’s no suggestion here that the lipid nanoparticles or their precious mRNA contents might get into the circulation. This idealised view is expressed widely, such as here, here and here.




